Endocrine Abstracts

A large number of endocrine pathologies can be associated to abnormalities in carbohydrate tolerance up to diabetes. The latter participates in the high risk of cardiovascular morbidity and mortality during these pathologies. The aim of our study was to assess the cardiovascular risk in a diabetic population suffering from an endocrine pathology. This is a retrospective study conducted in the department of endocrinology at Charles Nicolle Hospital involving 54 patients hospita...

TSH-secreting pituitary tumors (TSH-omas) are a rare cause of hyperthyroidism and account for < 1% of all pituitary adenomas. They are usually benign adenomas arising from a monoclonal expansion of neoplastic thyrotropes.We report two patients’ cases with thyrotropinoma.The first case is a 73-year-old woman, who presents a TSH-secreting pituitary adenoma in the setting of multiple endocrine neoplasia syndrome type 1 (TSH-o...

Introduction: Several familial disorders could be associated with adrenal pheochromocytoma such as Von Hippel–Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN2) and, less commonly, neurofibromatosis type 1 (NF1). Herein, we report three cases of pheochromocytoma as a part of genetic syndromes.ObservationsPatient 1A 34-year-old women with no familial history, was diagnosed with severe hype...

Introduction: Gougerot disease is an autoimmune disorder characterized by the lymphoid infiltration of salivary and lachrymal glands leading to the two most common symptoms dry eyes and a dry mouth. Primary hyperparathyroidism (PHPT), one of the most common endocrine disorders, is usually diagnosed by the association of hypercalcemia and parathyroid hormone (PTH) levels that are either elevated or inappropriately normal. The association of PHPT with Gougerot disease is rare, o...

Introduction: Clinical presentation of hypothyroidism is frequently insidious. Of the many non specific clinical signs of hypothyroidism, ascites is one of the less common manifestations reported and the diagnosis is often made late with this condition. Herein, we present the cases of isolated ascites revealing hypothyroidism in order to drow attention to hypothyroidism as an etiology of an unexplained isolated ascites.Observation: A 61-year-old diabetic...

Introduction: Autoimmune polyendocrine syndrome ( APS ) is a rare, inherited disorder, characterized by autoimmune thyroiditis with another organ specific autoimmune disease.ObservationWe report the case of 55 years old woman, descendant of a first degree consanguineous marriage, who presented at the age of 35 a premature ovarian insufficiency and alopecia. Eight months later, she developed a goiter with hyperthyroidism and the dia...

Multiple endocrine neoplasia type 1 (MEN1) is a rare but misleading disease. The diagnosis is evocated when two main lesions are present (parathyroid, pituitary gland, endocrine pancreas tumor: Gastrinoma). We studied a 36 year-old woman hospitalized in orthopedics for a neck femur fracture. A hypercalcaemia (Ca++=2.84 mmol/l) with elevated PTH=500 pg/ml were discovered before intervention. The bone biopsy concluded to primary hyperparathyroidism lesions.<p class="abstext"...

We report a 25 years old man who admitted in our department for primary hyperparathyroidism. He has previously been diagnosed with urolithiasis in 2006 and two pathological fracture of the humerus in 2009.Physical exam was normal laboratory findings showed hypercalcemia (4.06 mmol/l) associated to a high parathyroid hormone level (PTH: 1930 pg/ml).Ultrasound examination of the neck showed two enlarged parathyroid adenoma.<p cla...

Spontaneous pregnancy in the course of Sheehan syndrome is extremely rare because of gonadotrophic insufficiency, which is almost present.The aim of our study is to analyse cases of pregnancies occurring spontaneously in patients with Sheehan syndrome.It is a retrospective study of 46 women who had a Sheehan syndrome diagnosed in the Internal Medicine and endocrinology department of Charles Nicolle Hospital during the period betwee...

Sheehan syndrome is a global or partial pituitary defect occurring after an obstetrical haemorrhage.The aim of this study is to describe metabolic complications in 46 consecutive patients with Sheehan syndrome and to determine correlations between these complications and the clinical, hormonal and therapeutic aspects of this syndrome.All patients have had a physical examination: weight measurement, body mass index (BMI) determinati...